TRIM38 inhibits TNF - and IL-1 -triggered NF- B activation by mediating lysosome-dependent degradation of TAB2/3

TRIM38 inhibits TNFα- and IL-1β-triggered NF-κB activation by mediating lysosome-dependent degradation of TAB2/3.

TNFα and IL-1β are two proinflammatory cytokines that play critical roles in many diseases, including rheumatoid arthritis and infectious diseases. How TNFα- and IL-1β-mediated signaling is finely tuned is not fully elucidated. Here, we identify tripartite-motif protein 38 (TRIM38) as a critical negative regulator of TNFα- and IL-1β-triggered signaling. Overexpression of TRIM38 inhibited activa...

Induction of Macrophage-Inflammatory Protein-3 Gene Expression by TNF-Dependent NF- B Activation

Poxvirus Protein MC132 from Molluscum Contagiosum Virus Inhibits NF-B Activation by Targeting p65 for Degradation.

Molluscum contagiosum virus (MCV) is unique in being the only known extant, human-adapted poxvirus, yet to date, it is very poorly characterized in terms of host-pathogen interactions. MCV causes persistent skin lesions filled with live virus, but these are generally immunologically silent, suggesting the presence of potent inhibitors of human antiviral immunity and inflammation. Fewer than fiv...

Recruitment of TNF Receptor 1 to Lipid Rafts Is Essential for TNF -Mediated NF- B Activation

of TNFR1 leads to the recruitment of the death domain (DD)-containing adaptor molecule TNFR1-associated death domain protein (TRADD), which serves as a platDaniel F. Legler,1,2,* Olivier Micheau,1 Marie-Agnès Doucey,1 Jürg Tschopp,1 and Claude Bron1 form to recruit additional mediators (Hsu et al., 1995, Institute of Biochemistry 1996). TRADD, in turn, binds the DD-containing Ser/ University of...

NF- B induced by IL-1 inhibits elastin transcription and myofibroblast phenotype

[PDF] [Full Text] [Abstract] , April 1, 2007; 292 (4): L944-L952. Am J Physiol Lung Cell Mol Physiol Subramanian and Ronald H. Goldstein Ping-Ping Kuang, Xiao-Hui Zhang, Celeste B. Rich, Judith A. Foster, Mangalalaxmy fibroblasts in human lung β Activation of elastin transcription by transforming growth factor[PDF] [Full Text] [Abstract] , November 26, 2007; 101 (11): 1175-1184. Circulation...